It runs the RSA Labs 72-bit secret-key challenge, trying to crack 72-bit encryption.
According to their status page at their current rate they will test all keys in about 650 years

It works on all cuda capable cards
So if you have a cuda v1.0 based card (like 8800GTX) that gpugrid won't run on, Distributed.net will run

You need to be running the cuda 2.0 drivers, cuda 1.1 and cuda 2.1 drivers won't work.
You also need to install the cuda 2.0 toolkit.
You can find the cuda driver and toolkit, on Nvidia's Cuda download page
Just pick your OS and download the cuda 2.0 driver and cuda 2.0 toolkit, not the cuda 2.1 version!
You can get the Distributed.net cuda app from their pre-release page.
Available for Win x86 (will run on x64),Mac OSx/Darwin & Linux x86/x64.
Just extract the files from the .zip, move the folder to somewhere sensible and run the .exe file, 1st time run it will ask you to config it, basically just put an e-mail address in, save & exit and run it again.
It does use up 1 core, however boinc plays nice with it, you will lose some performance from Boinc and distributed.net.
The 4 cpu's running Boinc are saying 75% usage for each core, and distributed.net dropped from 330,xxx,xxx keys a sec to 300,xxx,xxx keys a sec, on my 9800GTX+
No Boinc credit of course, but it's something else to try
